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Cost-Effectiveness Analysis of PEG-rhG-CSF as Primary Prophylaxis to Chemotherapy-Induced Neutropenia in Patients with Epithelial Ovarian Cancer in China: Based on Real-Word Data
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LIANG Yan1, ZHAO Jie1, LI Jia1, LOU Xiaofei1, QIAO Gaoxing1, ZHANG Rui1, HU Wei2, LI Junfang3, ZUO Xu4, DU Shuzhang1, *
Chinese Pharmaceutical Journal | 2024, 59(4) : 363 - 368
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Chinese Pharmaceutical Journal | 2024, 59(4): 363-368
Cost-Effectiveness Analysis of PEG-rhG-CSF as Primary Prophylaxis to Chemotherapy-Induced Neutropenia in Patients with Epithelial Ovarian Cancer in China: Based on Real-Word Data
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LIANG Yan1, ZHAO Jie1, LI Jia1, LOU Xiaofei1, QIAO Gaoxing1, ZHANG Rui1, HU Wei2, LI Junfang3, ZUO Xu4, DU Shuzhang1, *
Affiliations
  • 1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China
  • 2 Department of Pharmacy, Xinyang Central Hospital, Xinyang, 464099, China
  • 3 Department of Pharmacy, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471003, China
  • 4 Department of Pharmacy, Xinxiang Central Hospital, Xinxiang, 453099, China
Published: 2024-02-22 doi: 10.11669/cpj.2024.04.010
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OBJECTIVE To evaluate the cost-effectiveness of PEG-rhG-CSF versus rhG-CSF in patients with epithelial ovarian cancer in central China for preventing chemotherapy-induced neutropenia. METHODS Two Markov models form healthcare system perspective were developed to evaluate the economics of PEG-rhG-CSF versus rhG-CSF using cost-utility analysis. Cost and probability input data were primarily obtained from a retrospective real-world study conducted in four tertiary hospitals from January 2019 to December 2020. One-way sensitivity analysis,probability sensitivity analysis and scenario analysis were used to verify the robustness of the results. RESULTS The basic analysis showed that, compared with rhG-CSF, PEG-rhG-CSF resulted in higher QALYs and lower cost, gained 0.27 QALYs more while spending 2279.63 yuan less, and the incremental cost-effectiveness ratios were ￥-8393.9/QALY. Sensitivity analysis and scenario analysis revealed robust results. CONCLUSION PEG-rhG-CSF is economically advantageous in Chinese patients with epithelial ovarian cancer for preventing chemotherapy-induced neutropenia.

PEG-rhG-CSF  /  rhG-CSF  /  real-world  /  neutropenia  /  cost-utility analysis
LIANG Yan, ZHAO Jie, LI Jia, LOU Xiaofei, QIAO Gaoxing, ZHANG Rui, HU Wei, LI Junfang, ZUO Xu, DU Shuzhang. Cost-Effectiveness Analysis of PEG-rhG-CSF as Primary Prophylaxis to Chemotherapy-Induced Neutropenia in Patients with Epithelial Ovarian Cancer in China: Based on Real-Word Data[J]. Chinese Pharmaceutical Journal, 2024 , 59 (4) : 363 -368 . DOI: 10.11669/cpj.2024.04.010
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doi: 10.11669/cpj.2024.04.010
  • Receive Date：2023-06-30
  • Online Date：2025-11-13
  • Published：2024-02-22
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  • Received：2023-06-30
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Affiliations
    1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China
    2 Department of Pharmacy, Xinyang Central Hospital, Xinyang, 464099, China
    3 Department of Pharmacy, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471003, China
    4 Department of Pharmacy, Xinxiang Central Hospital, Xinxiang, 453099, China
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https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.04.010
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