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Advances of siRNA Nano-Delivery System Based on Penetration of Blood-Brain Barrier
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SU Feng1, 3, XIONG Feng2, CAO Junru4, CHU Xiaoqin2, HE Guangwei2, 3, *, YIN Lifang1, *
Chinese Pharmaceutical Journal | 2024, 59(4) : 285 - 295
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Chinese Pharmaceutical Journal | 2024, 59(4): 285-295
Advances of siRNA Nano-Delivery System Based on Penetration of Blood-Brain Barrier
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SU Feng1, 3, XIONG Feng2, CAO Junru4, CHU Xiaoqin2, HE Guangwei2, 3, *, YIN Lifang1, *
Affiliations
  • 1 China Pharmaceutical University, Nanjing 211198, China
  • 2 Anhui University of Chinese Medicine, Hefei 230012, China
  • 3 Hefei Industrial Pharmaceutical Institute Co., Ltd., Hefei 230088, China
  • 4 Anhui Medical University, Hefei 230032, China
Published: 2024-02-22 doi: 10.11669/cpj.2024.04.001
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In recent years, central nervous system (CNS) diseases have become serious threat to human life and health. The existence of the blood-brain barrier (BBB), which prevents most drugs from entering the brain, has made the treatment of CNS diseases a major problem in the field of medicine and pharmacy. The advent of nanotechnology has given drugs the potential to penetrate the blood-brain barrier, and the rapid development of siRNA drugs has brought light to patients with CNS disorders. However, the delivery of nanocarriers to the brain encounters many obstacles and the conditions that can be met for brain delivery as siRNA nanocarriers are also very demanding. This paper therefore reviews the research progress and the advantages and disadvantages of lipokinase nanoparticles, chitosan nanoparticles, polyethyleneimine nanoparticles, dendrimer nanoparticles, nanogels, nanomicelles, nanoemulsions, exosomes, cells, and siRNA adducts as siRNA brain delivery systems, with a view to exploring a suitable siRNA nanodelivery system for blood-brain barrier penetration.

blood-brain barrier  /  siRNA  /  nanocarrier  /  central nervous system
SU Feng, XIONG Feng, CAO Junru, CHU Xiaoqin, HE Guangwei, YIN Lifang. Advances of siRNA Nano-Delivery System Based on Penetration of Blood-Brain Barrier[J]. Chinese Pharmaceutical Journal, 2024 , 59 (4) : 285 -295 . DOI: 10.11669/cpj.2024.04.001
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Article Info
doi: 10.11669/cpj.2024.04.001
  • Receive Date：2022-09-14
  • Online Date：2025-11-13
  • Published：2024-02-22
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  • Received：2022-09-14
Affiliations
    1 China Pharmaceutical University, Nanjing 211198, China
    2 Anhui University of Chinese Medicine, Hefei 230012, China
    3 Hefei Industrial Pharmaceutical Institute Co., Ltd., Hefei 230088, China
    4 Anhui Medical University, Hefei 230032, China
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https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.04.001
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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