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Progresses and Challenges in the Treatment of Rheumatoid Arthritis
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JIANG Ping1, 2, CHANG Cen2, 3, XU Linshuai2, SHI Yiming1, 2, HE Dongyi1, 2, 3, *
Chinese Pharmaceutical Journal | 2024, 59(3) : 200 - 209
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Chinese Pharmaceutical Journal | 2024, 59(3): 200-209
Progresses and Challenges in the Treatment of Rheumatoid Arthritis
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JIANG Ping1, 2, CHANG Cen2, 3, XU Linshuai2, SHI Yiming1, 2, HE Dongyi1, 2, 3, *
Affiliations
  • 1 Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200052, China
  • 2 Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 3 Arthritis Research Institute of Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200052, China
Published: 2024-02-08 doi: 10.11669/cpj.2024.03.002
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Rheumatoid arthritis(RA) is a chronic, systemic, and abnormal inflammatory immune response. It is characterized by the involvement of synovium and multiple organs and the destruction of joints and articular cartilage. In the past 30 years, some promising new compounds and antibodies have been developed to treat RA. The introduction of RA therapeutic drugs and the development of precision medicine have also given rise to several problems related to patients' access to new treatments, choice of the best regimen, cost-effectiveness, prognosis monitoring and efficacy monitoring, especially in terms of low drug response rate, drug resistance and adverse side effects. People attach great importance to the best combination of drugs for the treatment of RA, especially in patients with severe symptoms or early progression. New treatments and mechanisms are needed to solve these problems, and accurate guidelines for drug selection and drug recombination are established. According to the clinical trial database of the National Library of Medicine, this study summarizes the exciting new drugs, and discusses the trends and challenges in the development of RA drugs, which provides a meaningful reference for the accurate treatment and future research direction of RA.

rheumatoid arthritis  /  precision medicine  /  new therapy  /  drug development
JIANG Ping, CHANG Cen, XU Linshuai, SHI Yiming, HE Dongyi. Progresses and Challenges in the Treatment of Rheumatoid Arthritis[J]. Chinese Pharmaceutical Journal, 2024 , 59 (3) : 200 -209 . DOI: 10.11669/cpj.2024.03.002
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Article Info
doi: 10.11669/cpj.2024.03.002
  • Receive Date：2023-09-12
  • Online Date：2025-11-13
  • Published：2024-02-08
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  • Received：2023-09-12
Funding
Affiliations
    1 Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200052, China
    2 Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3 Arthritis Research Institute of Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200052, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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