OBJECTIVE To establish a method for the determination of 32 elements in COVID-19 vaccine. OBJECTIVE The 32 elements were determined by inductively coupled plasma optical emission spectrometer(ICP-OES) through semi-quantitative screening and quantitative detection, and the specificity, linearity, limit of quantification, detection limit and recovery rate of the ICP-OES method were investigated to evaluate the feasibility of the method for the detection of trace elements in vaccines. RESULTS The linear relationship of each element was good within the detection mass concentration range, and the recoveries of element added were 94.06%-115.50%. When applied to the detection of the samples at each accelerated placement point, except for the trace contents of B and Si elements, which did not increase significantly after long-term placement, the contents of other elements were far less than the prescribed limits. CONCLUSION The ICP-OES method is established. And the method has good specificity, reliable results, simple and rapid, and is suitable for the determination of 32 elements in COVID-19 vaccine.

ICP-OES  /  COVID-19 vaccine  /  32 element