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Simultaneous Determination of Twenty five Components in the Reference Sample of Banxiabaizhutianma Decoction by UHPLC-MS/MS
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CAI Yuluo1, GUO Jiahui1, ZHEN Yaqin1, 2, 3, JIANG Guozhi2, 4, TIAN Wei1, 2, 3, *, NIU Liying1, 2, 3, *
Chinese Pharmaceutical Journal | 2024, 59(1) : 88 - 96
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Chinese Pharmaceutical Journal | 2024, 59(1): 88-96
Simultaneous Determination of Twenty five Components in the Reference Sample of Banxiabaizhutianma Decoction by UHPLC-MS/MS
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CAI Yuluo1, GUO Jiahui1, ZHEN Yaqin1, 2, 3, JIANG Guozhi2, 4, TIAN Wei1, 2, 3, *, NIU Liying1, 2, 3, *
Affiliations
  • 1 Hebei University of Chinese Medicine, Shijiazhuang 050091, China
  • 2 Hebei TCM Formula Granule Innovation Center, Shijiazhuang 050091, China
  • 3 Hebei TCM Quality Evaluation Standardization Engineering Research Center, Shijiazhuang 050091, China
  • 4 Shineway Pharmaceutical Group Company Limited, Shijiazhuang 051430, China
Published: 2024-01-08 doi: 10.11669/cpj.2024.01.011
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OBJECTIVE To establish a UHPLC-MS/MS method for the simultaneous content determination of Adenosine, guanosine, succinic acid, trigonelline, gastrodin, parishin A, parishin B, parishin C, parishin E, atractylenolide Ⅱ, atractylenolide Ⅲ, chlorogenic acid, neochlorogenic acid, narirutin, hesperidin, rutin, naringin, tangeretin, poricoic acid A, liquiritin, glycyrrhizic acid, liquiritigenin, isoliquiritin, isoliquiritin apioside, cyclic AMP. METHODS The Shim-pack GIST C18 (2.1 mm×100 mm, 2 μm) column was used, the mobile phase was acetonitrile -0.1% formic acid, gradient elution, flow rate 0.3 mL·min-1; injection volume 1 μL. ESI ion source for positive and negative ion scanning analysis using multiple reaction monitoring (MRM) mode. RESULTS All of the analytes showed good linearity (r≥0.991) in the tested ranges. The precision, repeatability and stability of the method were good for the twenty five components. The average recoveries were 95.57%-104.98% with the RSDs of 0.55%-4.68%. CONCLUSION This method is strong exclusivity and high sensitivity, which can provide experimental basis for the quality control research of Banxiabaizhutianma Decoction.

Banxiabaizhutianma decoction  /  benchmark sample  /  UHPLC-MS/MS  /  content determination  /  quality control
CAI Yuluo, GUO Jiahui, ZHEN Yaqin, JIANG Guozhi, TIAN Wei, NIU Liying. Simultaneous Determination of Twenty five Components in the Reference Sample of Banxiabaizhutianma Decoction by UHPLC-MS/MS[J]. Chinese Pharmaceutical Journal, 2024 , 59 (1) : 88 -96 . DOI: 10.11669/cpj.2024.01.011
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Year 2024 volume 59 Issue 1
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Article Info
doi: 10.11669/cpj.2024.01.011
  • Receive Date：2022-10-08
  • Online Date：2025-11-12
  • Published：2024-01-08
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  • Received：2022-10-08
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Affiliations
    1 Hebei University of Chinese Medicine, Shijiazhuang 050091, China
    2 Hebei TCM Formula Granule Innovation Center, Shijiazhuang 050091, China
    3 Hebei TCM Quality Evaluation Standardization Engineering Research Center, Shijiazhuang 050091, China
    4 Shineway Pharmaceutical Group Company Limited, Shijiazhuang 051430, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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