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Research Progress of Analysis Methods in vivo for Anti-tumor Drug Liposomes
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ZHANG Qi, SUN Yaqi, GAO Jinglin, NIE Xuyang, FENG Zhangying, WANG Mingxia
Chinese Pharmaceutical Journal | 2024, 59(1) : 1 - 6
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Chinese Pharmaceutical Journal | 2024, 59(1): 1-6
Research Progress of Analysis Methods in vivo for Anti-tumor Drug Liposomes
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ZHANG Qi, SUN Yaqi, GAO Jinglin, NIE Xuyang, FENG Zhangying, WANG Mingxia
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  • Department of Clinical Pharmacology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
Published: 2024-01-08 doi: 10.11669/cpj.2024.01.001
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Anti-tumor drugs have high toxicity and adverse reactions. Liposome formulation can reduce drug toxicity and degradation of drug activity, which is a promising target vector. At present, the pharmacokinetic study of most anti-tumor drug liposomes mainly takes the total concentration as the index, but the free drugs are the part that really plays the pharmacological effect in vivo. So the separation and determination of the free drugs are very important. Sample pretreatment is a key step in the separation and extraction of free drugs after liposome administration. This article focuses on common detection methods, pretreatment methods and analysis examples, to provide reference for the establishment of analysis methods in vivo for anti-tumor drug liposomes.

anti-tumor drug  /  liposome  /  in vivo analysis  /  sample pretreatment  /  free concentration
ZHANG Qi, SUN Yaqi, GAO Jinglin, NIE Xuyang, FENG Zhangying, WANG Mingxia. Research Progress of Analysis Methods in vivo for Anti-tumor Drug Liposomes[J]. Chinese Pharmaceutical Journal, 2024 , 59 (1) : 1 -6 . DOI: 10.11669/cpj.2024.01.001
Year 2024 volume 59 Issue 1
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doi: 10.11669/cpj.2024.01.001
  • Receive Date:2022-08-14
  • Online Date:2025-11-12
  • Published:2024-01-08
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  • Received:2022-08-14
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    Department of Clinical Pharmacology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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