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OBJECTIVE To prepare chitosan (CS)/sodium alginate (SA) hydrogel (GelCA@LUT) loaded with luteolin (LUT) nanoparticles (NPs@LUT) as a wound dressing and evaluate its physicochemical properties, as well as its safety. METHODS NPs@LUT were prepared by an emulsion-solvent evaporation method, and hydrogels (GelCA) with different contents of cross-linking agents (genipin) and different CS/SA quality ratios were prepared. Then, the wound dressing (GelCA@LUT) was obtained by coating NPs@LUT on the surface of GelCA. The properties of the hydrogel were evaluated by measuring water vapor transmission rate, water content, water retention, swelling properties, porosity, and rheological properties. The structure and morphology of the hydrogel were characterized using Fourier transform infrared spectroscopy (FTIR), transmission (TEM), and scanning electron microscopy (SEM). The release profiles of LUT from NPs@LUT and GelCA@LUT was examined in different concentrations of hydrogen peroxide/PBS buffer; hemocompatibility and cytotoxicity were tested by hemolytic and cytotoxicity assays, respectively. RESULTS The characterization results showed that the average particle size of NPs@LUT was (234.3±4.7) nm, the drug loading rate was (9.54±0.10)%, and the encapsulation efficiency was (85.35±0.95)%. GelCA with a mass ratio of CS to SA at 1∶2 and a cross-linking agent dosage of 1.0 mg was successfully constructed. Both NPs@LUT and GelCA@LUT could release LUT stably, and GelCA@LUT had good biocompatibility. CONCLUSION GelCA@LUT can accelerate wound regeneration by substantially improving the wound microenvironment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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