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Secondary Metabolites and Hypolipidemic Activities of Irpex lacteus
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Tangjie ZHANG1, Zhenxin ZHU2, Jing YAN1, Minghe JIANG3, Hongcun LIU2, Juan MENG4, Xuan ZHANG1, 5, Chaonan KONG1, Lifang YANG1, 5, *
Chinese Pharmaceutical Journal | 2025, 60(8) : 793 - 800
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Chinese Pharmaceutical Journal | 2025, 60(8): 793-800
Secondary Metabolites and Hypolipidemic Activities of Irpex lacteus
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Tangjie ZHANG1, Zhenxin ZHU2, Jing YAN1, Minghe JIANG3, Hongcun LIU2, Juan MENG4, Xuan ZHANG1, 5, Chaonan KONG1, Lifang YANG1, 5, *
Affiliations
  • 1 School of Chemistry and Chemical Engineering, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Education Department of Guangxi Zhuang Auto Nomous Region, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China
  • 2 Guangxi Key Laboratory of Polysaccharide Materials and Modification, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning 530008, China
  • 3 Rui Kang Hospital Affiliated With Guangxi University of Traditional Chinese Medicine, Nanning 530011, China
  • 4 College of Preparatory Education, Guangxi Minzu University, Nanning 530008, China
  • 5 NMPA Key Laboratory for Quality Manitoring and Evaluation of Traditional Chinese Medicines, Chinese Materia Medica, Guangxi Institute for Food and Drug Control, Nanning 530021, China
Published: 2025-04-15 doi: 10.11669/cpj.2025.08.003
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OBJECTIVE To investigate the secondary metabolites and hypolipidemic properties of Irpex lacteus. METHODS Compounds were isolated and purified using silica gel column chromatography, preparative high-performance liquid chromatography (Pre-HPLC), and other chromatographic techniques. Structural identification was performed through nuclear magnetic resonance (NMR), high-resolution mass spectrometry, infrared (IR), and ultraviolet (UV) spectroscopy. HepG2 cell model with high lipid was established to test the hypolipidemic activity. RESULTS Twelve compounds were isolated from Irpex lacteus and identified as (2α, 4β, 5β, 7β, 10α)-2, 5, 11-eudesmanetriol(1), 11, 12-epoxy-5, 6-secotremula-1, 6(13)-dien-5-12-olide(2), 8α, 10α-di-O-acetyl-lactarorufin A(3), (+)-(2S, 3R, 6S, 7S)-tremul-1(10)-ene-2, 12- diol(4), conocenolide A(5), irpexolactin G(6)、2, 2'-oxybis(1, 4-di-tert-butylbenzene) (7), 4'-hydroxy-5, 7-dimethoxy-6-(3-methyl-2-butenyl)- isoflavone(8), cyclo(Ile-Val) (9)、cyclo(L-Pro-L-Leu) (10), cyclo(Ile-Leu) (11), cyclo(Ile-lle) (12). The results of hypolipidemic activity showed that compounds 1-4, 8 and 9 had hypolipidemic activities, and the reduction effect of TG content in each dose group of compounds 1, 4 and the high and medium dose groups of compounds 2, 3 and 8 was better than that of the positive drug group. CONCLUSION Compounds 1-4, 7-12 are isolated from this strain for the first time. Compounds 1-4, 8 and 9 have good hypolipidemic effects.

Irpex lacteus  /  fermentation conditions optimization  /  secondary metabolites  /  hypolipidemic activity
Tangjie ZHANG, Zhenxin ZHU, Jing YAN, Minghe JIANG, Hongcun LIU, Juan MENG, Xuan ZHANG, Chaonan KONG, Lifang YANG. Secondary Metabolites and Hypolipidemic Activities of Irpex lacteus[J]. Chinese Pharmaceutical Journal, 2025 , 60 (8) : 793 -800 . DOI: 10.11669/cpj.2025.08.003
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Article Info
doi: 10.11669/cpj.2025.08.003
  • Receive Date：2024-10-08
  • Online Date：2025-11-12
  • Published：2025-04-15
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  • Received：2024-10-08
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Affiliations
    1 School of Chemistry and Chemical Engineering, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Education Department of Guangxi Zhuang Auto Nomous Region, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China
    2 Guangxi Key Laboratory of Polysaccharide Materials and Modification, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning 530008, China
    3 Rui Kang Hospital Affiliated With Guangxi University of Traditional Chinese Medicine, Nanning 530011, China
    4 College of Preparatory Education, Guangxi Minzu University, Nanning 530008, China
    5 NMPA Key Laboratory for Quality Manitoring and Evaluation of Traditional Chinese Medicines, Chinese Materia Medica, Guangxi Institute for Food and Drug Control, Nanning 530021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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