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Optimization of Extraction Process for Erxian Decoction Based on Standard Relation and AHP-Entropy Weight Method
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Min ZHANG1, 2, 3, 4, Xueyan HUANG1, 2, 3, Qingxiang ZENG1, 2, 3, Xiaoyu WU1, 2, 3, Xiaoxia LIU1, 2, 3, Xiaoli FENG1, 2, 3, Wenrui FU1, 2, 3, Shuchang WEI1, 2, 3, *
Chinese Pharmaceutical Journal | 2025, 60(8) : 801 - 808
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Chinese Pharmaceutical Journal | 2025, 60(8): 801-808
Optimization of Extraction Process for Erxian Decoction Based on Standard Relation and AHP-Entropy Weight Method
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Min ZHANG1, 2, 3, 4, Xueyan HUANG1, 2, 3, Qingxiang ZENG1, 2, 3, Xiaoyu WU1, 2, 3, Xiaoxia LIU1, 2, 3, Xiaoli FENG1, 2, 3, Wenrui FU1, 2, 3, Shuchang WEI1, 2, 3, *
Affiliations
  • 1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000 China
  • 2 Gansu Province Traditional Chinese Medicine Pharmaceutical Technology Engineering Research Center, Lanzhou 730000 China
  • 3 Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou 730000 China
  • 4 Gansu Medical College, Pingliang 744000 China
Published: 2025-04-15 doi: 10.11669/cpj.2025.08.004
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OBJECTIVE To ensure the equivalence of the ancient and modern processes, and optimize the alcohol extractionprocess of Erxian Decoction(EXD), using standard relation andanalytic hierarchy process(AHP)-entropy weight method combinedwith Box-Behnken response surface method. METHODS Taking phellodendrine, mangiferin, ferulic acid, berberine, curculigoside, epmedin A1, epmedin A, epmedin B, epmedin C, icariin content, dry extract rate and fingerprint similarity as the key quality factors, taking ethanol concetration, solid-liquid ratio and extraction time as the key process parameters, the best extraction process was obtained by Box-Behnken response surface method. RESULTS The optimal conditions were 75% ethanol, 1∶14 solid-liquid ratio (g∶mL) and 62 min extraction time. The verified experimental results showed that the average comprehensive score was 86.64, and the relative standard deviation(RSD) was 1.02%. CONCLUSION The alcohol extraction process of EXD is optimized using standard relation combined with AHP-entropy weight method, the fitted model is significant, and the quality of the standard decoction is highly consistent, which provids a reference for the change of dosage form in the later stage.

Erxian Decoction  /  alcohol extraction process  /  Box-Behnken response surface method  /  standard relation  /  AHP-entropy weight method
Min ZHANG, Xueyan HUANG, Qingxiang ZENG, Xiaoyu WU, Xiaoxia LIU, Xiaoli FENG, Wenrui FU, Shuchang WEI. Optimization of Extraction Process for Erxian Decoction Based on Standard Relation and AHP-Entropy Weight Method[J]. Chinese Pharmaceutical Journal, 2025 , 60 (8) : 801 -808 . DOI: 10.11669/cpj.2025.08.004
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Year 2025 volume 60 Issue 8
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doi: 10.11669/cpj.2025.08.004
  • Receive Date：2024-10-08
  • Online Date：2025-11-12
  • Published：2025-04-15
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  • Received：2024-10-08
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Affiliations
    1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000 China
    2 Gansu Province Traditional Chinese Medicine Pharmaceutical Technology Engineering Research Center, Lanzhou 730000 China
    3 Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou 730000 China
    4 Gansu Medical College, Pingliang 744000 China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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