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Long-acting injectable formulations are preferred over conventional formulations for the treatment of chronic diseases. An effort to build the relationship between an in-vivo property of a dosage form and an in-vitro response is often referred to as“in vitro-in vivo correlation” (IVIVC) analysis. This paper provides an overview of the classification, establishment and evaluation method of IVIVC. Due to long-acting injectable formulations' diverse nature, it is impractical to establish an universal IVIVC model in vitro, it is essential to develop individual IVIVC model in every study. Integrated knowledges of physicochemical, dosage form design and the interaction of the drug molecule with site of administration play important roles in the study of long-acting injectable formulations' IVIVC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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