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Reproductive Toxicity Mechanism of Tripterygium wilfordii Tablet Based on Gut Microbiota and Metabolomics
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Liqiong CHEN1, 2, Jiahui CHEN1, 2, Bin LI1, Dongmei YAN1, Yan CHENG1, Ting ZHANG2, 3, Fei LI2, *
Chinese Pharmaceutical Journal | 2025, 60(9) : 907 - 914
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Chinese Pharmaceutical Journal | 2025, 60(9): 907-914
Reproductive Toxicity Mechanism of Tripterygium wilfordii Tablet Based on Gut Microbiota and Metabolomics
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Liqiong CHEN1, 2, Jiahui CHEN1, 2, Bin LI1, Dongmei YAN1, Yan CHENG1, Ting ZHANG2, 3, Fei LI2, *
Affiliations
  • 1 Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2 Laboratory of Hepatointestinal Diseases and Metabolism, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China
  • 3 Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611100, China
Published: 2025-05-01 doi: 10.11669/cpj.2025.09.002
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OBJECTIVE To investigate the toxic mechanisms of Tripterygium wilfordii tablet(TWT) causing male mice reproductive damage and to identify detoxification targets. METHODS TWT was used to induce reproductive injury in mice. Metagenomic and metabolomics analysis were employed to perform differential analysis and functional analysis of gut microbiota and metabolites, aiming to identify the causative strains and metabolic pathways for reproductive injury, and to elucidate the mechanisms by which the microbiota and metabolites affect reproductive injury. RESULTS TWT significantly reduced the testicular index and sperm count in mice, leading to oxidative stress in testicular tissues. And TWT disrupted the gut microbiota and testicular metabolism. Supplementation with exogenous indole-3-lactic acid and Lactobacillus reuteri could regulate oxidative stress and improve testicular damage induced by TWT. CONCLUSION TWT cause reproductive damage by disrupting the gut microbiota and testicular metabolism. Lactobacillus reuteri and its metabolite, indole-3-lactic acid, improve male mice reproductive damage induced by TWHF tablets by regulating oxidative stress in testicular tissues.

Tripterygium wilfordii tablet  /  reproductive injury  /  gut microbiota  /  metabolomics
Liqiong CHEN, Jiahui CHEN, Bin LI, Dongmei YAN, Yan CHENG, Ting ZHANG, Fei LI. Reproductive Toxicity Mechanism of Tripterygium wilfordii Tablet Based on Gut Microbiota and Metabolomics[J]. Chinese Pharmaceutical Journal, 2025 , 60 (9) : 907 -914 . DOI: 10.11669/cpj.2025.09.002
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Article Info
doi: 10.11669/cpj.2025.09.002
  • Receive Date：2024-07-24
  • Online Date：2025-11-11
  • Published：2025-05-01
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  • Received：2024-07-24
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Affiliations
    1 Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2 Laboratory of Hepatointestinal Diseases and Metabolism, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China
    3 Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611100, China
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https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2025.09.002
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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