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OBJECTIVE To investigate the secondary metabolites and bioactivities of the mangrove Rhizophora stylosa derived fungus Diaporthe sp. SCSIO 41011. METHODS Various modern chromatographic methods were subjected to isolate and purify the fermentation products of the strain. The chemical structures of the obtained compounds were identified by nuclear magnetic resonance technology as well as literature data. The antibacterial activity, NF-κB luciferase inhibitory activity, and antioxidant activity of the compounds were determined. The antioxidant activity of the compounds was determined by 1,1-diphenyl-2-picrylhydrazy (DPPH) and ferric reducing ability of plasma (FRAP). RESULTS Seven compounds (1-7) were isolated from the fermentation products and were identified as nigrosporapyrone D (1), vermopyrone (2), tyrosol (3), 2-(2-hydroxyethyl)phenol (4), 3-phenylpropane-1,2-diol (5), 4-hydroxyphenethyl acetate (6), 2-hydroxyphenethyl acetate (7). The chemical structure of 2 was confirmed by X-ray single-crystal diffraction method for the first time herein. At the concentration of 1 mg·mL-1, the FRAP values of compounds 3, 6, and 7 were 208.75, 160.03, and 162.75 μmol·L-1, respectively. CONCLUSION Two pyranones (1 and 2) and five phenolic compounds (3-7) are characterized from the fungus, meanwhile compounds 1, 2, 4, 5, and 7 are isolated from the Diaporthe genus for the first time. And compounds 3, 6, and 7 show iron ion reduction/antioxidant capacity. This study would enrich the structural diversity of secondary metabolites of Diaporthe sp., and lays a foundation for further study on the natural products of mangrove endophytic fungi.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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