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Development of Anti-gout Biological Potency Determination Method for Phellodendri Chinensis Cortex Based on Electrochemical Biosensing Technology and Its Application in Quality Evaluation
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Jingrong LI1, 2, 3, Yuzhuo ZHU1, 2, 3, Xueqi WANG1, 2, 3, Zhaoming CHENG1, 2, 3, Chuanjun ZHANG1, 2, 3, Boshi LIU1, 2, 3, Di ZHANG1, 2, 3, *
Chinese Pharmaceutical Journal | 2025, 60(7) : 747 - 754
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Chinese Pharmaceutical Journal | 2025, 60(7): 747-754
Development of Anti-gout Biological Potency Determination Method for Phellodendri Chinensis Cortex Based on Electrochemical Biosensing Technology and Its Application in Quality Evaluation
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Jingrong LI1, 2, 3, Yuzhuo ZHU1, 2, 3, Xueqi WANG1, 2, 3, Zhaoming CHENG1, 2, 3, Chuanjun ZHANG1, 2, 3, Boshi LIU1, 2, 3, Di ZHANG1, 2, 3, *
Affiliations
  • 1 College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2 Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin 301617, China
  • 3 Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
Published: 2025-04-08 doi: 10.11669/cpj.2025.07.010
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OBJECTIVE To determine the xanthine oxidase (XO) inhibitory activity of Phellodendri Chinensis Cortex based on electrochemical biosensor to establish the evaluation method for anti-gout biological potency and compare the quality combined with chemical content determination, thus to provide a new model of overall quality assessment of Phellodendri Chinensis Cortex. METHODS The contents of berberine and phellodendrine in Phellodendri Chinensis Cortex samples were determined by high performance liquid chromatography (HPLC). The anti-gout biological potency was investigated by electrochemical biosensor. And Pearson correlation analysis was used to calculate the correlation between biological potency and chemical components of Phellodendri Chinensis Cortex. RESULTS The chemical content of Phellodendri Chinensis Cortex in each batch met the requirements of the Chinese Pharmacopoeia 2020: the content of berberine was 5.09% to 34.76%, and the content of phellodendrine was 2.56% to 4.76%. The XO inhibitory activity of Phellodendri Chinensis Cortex samples varied greatly, and their biological potency ranged from 25.60 to 337.96 U·mg-1. In addition, Pearson correlation analysis showed that there was no significant correlation between berberine and phellodendrine contents and their anti-gout biological potency (P>0.05). CONCLUSION The established biological potency evaluation method with electrochemical biosensor can be used for the quality test of Phellodendri Chinensis Cortex, and the combination of chemical composition and biological potency can reflect the quality difference among Phellodendri Chinensis Cortex batches more objectively and reasonably.

Phellodendri Chinensis Cortex  /  xanthine oxidase  /  electrochemical biosensor  /  anti-gout biological potency  /  phellodendrine  /  berberine
Jingrong LI, Yuzhuo ZHU, Xueqi WANG, Zhaoming CHENG, Chuanjun ZHANG, Boshi LIU, Di ZHANG. Development of Anti-gout Biological Potency Determination Method for Phellodendri Chinensis Cortex Based on Electrochemical Biosensing Technology and Its Application in Quality Evaluation[J]. Chinese Pharmaceutical Journal, 2025 , 60 (7) : 747 -754 . DOI: 10.11669/cpj.2025.07.010
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Year 2025 volume 60 Issue 7
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Article Info
doi: 10.11669/cpj.2025.07.010
  • Receive Date：2024-12-26
  • Online Date：2025-11-11
  • Published：2025-04-08
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  • Received：2024-12-26
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Affiliations
    1 College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2 Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin 301617, China
    3 Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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