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OBJECTIVE To investigate the imatinib mesylate (IM) adherence and health-related quality of life (HRQoL) of gastrointestinal stromal tumor (GIST) patients, and further identify the influencing factors. METHODS Patients who visited the GIST specialty clinic between April 2022 and April 2024 were enrolled. All eligible patients completed a composite questionnaire, including the basic situation, adherence, HRQoL, and adverse events. Then the influencing factors of adherence and HRQoL were analyzed. RESULTS A total of 227 GIST patients were enrolled, and the IM adherence rate was 48.5%. The main non-adherence factors were living in rural area for extended periods, concomitant disease, without therapeutic drug monitoring (TDM), impaired cognitive function, pain, dyspnea, insomnia, fatigue, and gastrointestinal adverse effects. Multivariate logistic regression analysis showed that TDM and no pain were promoters of adherence. The risk factors for global health status were female, unemployment, monthly income less than 3000 yuan, concomitant medications and anemia, and such patients had lower functioning score and higher symptom burden. Multivariate logistic regression analysis showed that gender was a predictor of global health status. CONCLUSION Patients with GIST often exhibit low adherence to IM, and various factors can impact both adherence and HRQoL. In the future, medical workers can play a crucial role in providing medication education and guidance, adverse events management, TDM, and interventions for patients with specific risk factors to enhance IM adherence and overall well-being of patients with GIST.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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