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The RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) plays a pivotal role in the virus's replication process and is a primary target for nucleoside analogue antiviral drugs. However, the ongoing mutations of the virus have led to the emergence of multiple variants of concern, such as Alpha, Beta, Gamma, Delta, and Omicron, resulting in recurrent waves of the pandemic that are yet to be fully controlled. Although the RdRp of the novel coronavirus is relatively conserved, ongoing research has identified several mutations at this protein, such as V166A, V166L, and P323L. The impact of these mutations on the antiviral efficacy of currently available small molecule drugs is noteworthy. This article reviews the influence of SARS-CoV-2 RdRp mutations on resistance to remdesivir, incorporating protein structure prediction of the mutation sites, with the aim of providing insights for optimizing antiviral treatment strategies against COVID-19.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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