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C21 Steroids and Their Anti-Inflammatory Activities from Periplocae Cortex
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Shuxiu ZHAO1, Guodong HOU1, 2, Jing SUN1, Yaxin WANG1, 2, Cuihui BAI1, 2, Yujie DU1, 2, Qingzhi LIU2, Yongqiang LIN1, Dongxiao GUO1, *
Chinese Pharmaceutical Journal | 2025, 60(10) : 1026 - 1032
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Chinese Pharmaceutical Journal | 2025, 60(10): 1026-1032
C21 Steroids and Their Anti-Inflammatory Activities from Periplocae Cortex
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Shuxiu ZHAO1, Guodong HOU1, 2, Jing SUN1, Yaxin WANG1, 2, Cuihui BAI1, 2, Yujie DU1, 2, Qingzhi LIU2, Yongqiang LIN1, Dongxiao GUO1, *
Affiliations
  • 1 Shandong Engineering Research Center for Standard Innovation and Quality Evaluation of TCM, Shandong Engineering Research Center for Generic Technologies of Traditional Chinese Medicine Formula Granules, Shandong Institute for Food and Drug Control, Jinan 250101, China
  • 2 Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2025-05-01 doi: 10.11669/cpj.2025.10.004
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OBJECTIVE To study the chemical constituents and anti-inflammatory activity of Periplocae Cortex. METHODS The chemical components in Periplocae Cortex were extracted and isolated by MCI resin column, silica gel column and gel column, and the structure of the monomeric compounds was identified by nuclear magnetic resonance spectroscopy, mass spectrometry, infrared spectroscopy, etc. The Griess method was used to test the lipopolysaccharide-induced model of inflammatory factor release from mouse monocyte macrophage RAW264.7 cells, and the anti-inflammatory activity of the compound was evaluated. RESULTS A total of 6 compounds were isolated from Periplocae Cortex, including Δ5-pregnene-3β,20(S)-diol-3-O-[2-O-acetyl-β-D-digital-opyranosyl-(1→4)-β-D-cymaropyranoside]-20-O-[β-D-glucopyranosyl-(1→2)-β-D-digita-lopyranoside] (1), Δ5-pregnene-3β,17α,20α-triol (2), periplocoside L (3), periplocoside N (4), periplocogenin (5), periplocoside M (6). Compound 1 is a new compound, named periplocoside G1. In vitro anti-inflammatory activity studies showed that 1, 5, and 6 showed antiinflammatory activities. CONCLUSION The isolated and identified compounds and their activities provide a basis for the rational development and utilization of medicinal resources.

Periplocae Cortex  /  steroid  /  anti-inflammatory activity  /  Δ5-pregnene-3β,20(S)-diol-3-O-[2-O-acetyl-β-D-digitalopyranosyl-(1→4)-β-D-cymaropyranoside]-20-O-[β-D-glucopyranosyl-(1→2)-β-D-digitalopyranoside]  /  periplocoside G1
Shuxiu ZHAO, Guodong HOU, Jing SUN, Yaxin WANG, Cuihui BAI, Yujie DU, Qingzhi LIU, Yongqiang LIN, Dongxiao GUO. C21 Steroids and Their Anti-Inflammatory Activities from Periplocae Cortex[J]. Chinese Pharmaceutical Journal, 2025 , 60 (10) : 1026 -1032 . DOI: 10.11669/cpj.2025.10.004
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Year 2025 volume 60 Issue 10
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Article Info
doi: 10.11669/cpj.2025.10.004
  • Receive Date：2024-12-06
  • Online Date：2025-11-09
  • Published：2025-05-01
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  • Received：2024-12-06
Funding
Affiliations
    1 Shandong Engineering Research Center for Standard Innovation and Quality Evaluation of TCM, Shandong Engineering Research Center for Generic Technologies of Traditional Chinese Medicine Formula Granules, Shandong Institute for Food and Drug Control, Jinan 250101, China
    2 Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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