Home Journals Articles Updates About
CN
image
收藏切换
Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum
收藏切换
PDF
Zhengyuan SHI1, Jie XIE2, Ziying LI2, You JIANG2, Xiqiao XU1, Chunjing YANG1, Yanwei FU1, Dan YAN3, *
Chinese Pharmaceutical Journal | 2025, 60(2) : 180 - 183
Less
收藏切换
Chinese Pharmaceutical Journal | 2025, 60(2): 180-183
Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum
Full
Zhengyuan SHI1, Jie XIE2, Ziying LI2, You JIANG2, Xiqiao XU1, Chunjing YANG1, Yanwei FU1, Dan YAN3, *
Affiliations
  • 1 Department of Pharmacy,Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • 2 Technology Innovation Center of Mass Spectrometry for State Market Regulation, Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China
  • 3 Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Published: 2025-01-22 doi: 10.11669/cpj.2025.02.010
Outline
收藏切换

OBJECTIVE To analyze the consistency and correlation between UHPLC-MS/MS and chemiluminescence microparticle immune assay (CMIA) in measuring vancomycin concentration in serum.METHODS The concentration of vancomycin was measured by UHPLC-MS/MS and CMIA methods respectively in 95 serum samples of patients receiving vancomycin treatment. A correlation analysis and an agreement analysis were conducted for the two methods used linear regression and Bland-Altman method. RESULTS Based on the results of UHPLC-MS/MS(x) and CMIA(y), the linear regression equation was determined as follows: y=1.088x+0.174. Spearmen correlation analysis indicated a significant correlation between the results by the two methods (P<0.05), and the Spearmen correlation coefficient was 0.969 1. There was statistical difference between vancomycin serum concentrations measured by these two methods. The result was higher by CMIA compared with UHPLC-MS/MS. CONCLUSION The results of the two methods can be calculated to one another by equation, which provides reference for the formulation of clinical individualized medication plan.

vancomycin  /  serum  /  therapeutic drug monitoring  /  UHPLC-MS/MS  /  CMIA
Zhengyuan SHI, Jie XIE, Ziying LI, You JIANG, Xiqiao XU, Chunjing YANG, Yanwei FU, Dan YAN. Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum[J]. Chinese Pharmaceutical Journal, 2025 , 60 (2) : 180 -183 . DOI: 10.11669/cpj.2025.02.010
Appendix
Less
Year 2025 volume 60 Issue 2
PDF
268
129
Cite this Article
BibTeX
Article Info
doi: 10.11669/cpj.2025.02.010
  • Receive Date：2024-01-26
  • Online Date：2025-11-08
  • Published：2025-01-22
Article Data
Affiliations
History
  • Received：2024-01-26
Funding
Affiliations
    1 Department of Pharmacy,Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    2 Technology Innovation Center of Mass Spectrometry for State Market Regulation, Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China
    3 Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2025.02.010
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House