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Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum
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Zhengyuan SHI1, Jie XIE2, Ziying LI2, You JIANG2, Xiqiao XU1, Chunjing YANG1, Yanwei FU1, Dan YAN3, *
Chinese Pharmaceutical Journal | 2025, 60(2) : 180 - 183
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Chinese Pharmaceutical Journal | 2025, 60(2): 180-183
Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum
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Zhengyuan SHI1, Jie XIE2, Ziying LI2, You JIANG2, Xiqiao XU1, Chunjing YANG1, Yanwei FU1, Dan YAN3, *
Affiliations
  • 1 Department of Pharmacy,Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • 2 Technology Innovation Center of Mass Spectrometry for State Market Regulation, Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China
  • 3 Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Published: 2025-01-22 doi: 10.11669/cpj.2025.02.010
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OBJECTIVE To analyze the consistency and correlation between UHPLC-MS/MS and chemiluminescence microparticle immune assay (CMIA) in measuring vancomycin concentration in serum.METHODS The concentration of vancomycin was measured by UHPLC-MS/MS and CMIA methods respectively in 95 serum samples of patients receiving vancomycin treatment. A correlation analysis and an agreement analysis were conducted for the two methods used linear regression and Bland-Altman method. RESULTS Based on the results of UHPLC-MS/MS(x) and CMIA(y), the linear regression equation was determined as follows: y=1.088x+0.174. Spearmen correlation analysis indicated a significant correlation between the results by the two methods (P<0.05), and the Spearmen correlation coefficient was 0.969 1. There was statistical difference between vancomycin serum concentrations measured by these two methods. The result was higher by CMIA compared with UHPLC-MS/MS. CONCLUSION The results of the two methods can be calculated to one another by equation, which provides reference for the formulation of clinical individualized medication plan.

vancomycin  /  serum  /  therapeutic drug monitoring  /  UHPLC-MS/MS  /  CMIA
时正媛, 谢洁, 李姿颖, 江游, 续茜桥, 杨春静, 付延伟, 鄢丹. 超高效液相色谱-串联质谱法与化学发光微粒子免疫法测定万古霉素血药浓度的比较分析. 中国药学杂志, 2025 , 60 (2) : 180 -183 . DOI: 10.11669/cpj.2025.02.010
Zhengyuan SHI, Jie XIE, Ziying LI, You JIANG, Xiqiao XU, Chunjing YANG, Yanwei FU, Dan YAN. Comparison of UHPLC-MS/MS and Chemiluminescence Microparticle Immune Assay in Determination of Vancomycin Concentration in Human Serum[J]. Chinese Pharmaceutical Journal, 2025 , 60 (2) : 180 -183 . DOI: 10.11669/cpj.2025.02.010
Appendix
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Year 2025 volume 60 Issue 2
719
352
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Article Info
doi: 10.11669/cpj.2025.02.010
  • Receive Date：2024-01-26
  • Online Date：2025-11-08
  • Published：2025-01-22
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  • Received：2024-01-26
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Affiliations
    1 Department of Pharmacy,Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
    2 Technology Innovation Center of Mass Spectrometry for State Market Regulation, Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China
    3 Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
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https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2025.02.010
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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