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OBJECTIVE To investigate the synthesis and characterization of moxifloxacin hydrochloride. METHODS Using ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate and (S,S)-2,8-diazabicyclo[4.3.0] nonane as the starting materials, moxifloxacin hydrochloride was prepared through five steps: chelation, condensation, hydrolysis, salt formation, and refinement. RESULTS and CONCLUSION Compared with other routes, this route is of mild conditions, simple postprocessing, less impurities, high process safety, and less environmental pollution.The prominent advantage of this route is that it can effectively remove boric impurities from moxifloxacin. The chemical structures of the target moxifloxacin hydrochloride and its key intermediates were characterized by IR, HR-MS, XRD and NMR spectra, including 1H-NMR,1H-1HCOSY, 13C-NMR, DEPT, HSQC, and HMBC spectra.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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