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Progress in Clinical Trials of Aldose Reductase Inhibitors in the Treatment of Diabetic Peripheral Neuropathy
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Jian ZHOU, Lianhua FANG*, Yang LÜ, Guanhua DU
Chinese Pharmaceutical Journal | 2025, 60(6) : 553 - 558
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Chinese Pharmaceutical Journal | 2025, 60(6): 553-558
Progress in Clinical Trials of Aldose Reductase Inhibitors in the Treatment of Diabetic Peripheral Neuropathy
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Jian ZHOU, Lianhua FANG*, Yang LÜ, Guanhua DU
Affiliations
  • Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2025-03-22 doi: 10.11669/cpj.2025.06.001
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Diabetic peripheral neuropathy is one of the most common complications of diabetes. Aldose reductase is a key enzyme in the pathogenesis of diabetic complications. This review systematically reviews the efficacy and safety of five kinds of aldose reductase inhibitors in the treatment of diabetic peripheral nerves. Epalrestat is the only aldose reductase inhibitor in clinical application so far. A number of clinical trials have shown that epalrestat has a certain therapeutic effect on diabetic peripheral neuropathy and has sufficient safety, but long-term studies have shown that its therapeutic effect is not better than mecobalamine. Torrestat, zoporestat, ponastat, and fedastat were all withheld from the market or withdrawn from the market due to efficacy or safety concerns, which was inferred to be related to the structural characteristics of the drugs. Development of more effective and safer aldose reductase inhibitors from the perspective of drug structure will become one of the future research focuses on diabetic peripheral neuropathy.

aldose reductase inhibitor  /  diabetic peripheral neuropathy  /  clinic trial  /  epalrestat
Jian ZHOU, Lianhua FANG, Yang LÜ, Guanhua DU. Progress in Clinical Trials of Aldose Reductase Inhibitors in the Treatment of Diabetic Peripheral Neuropathy[J]. Chinese Pharmaceutical Journal, 2025 , 60 (6) : 553 -558 . DOI: 10.11669/cpj.2025.06.001
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Year 2025 volume 60 Issue 6
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doi: 10.11669/cpj.2025.06.001
  • Receive Date：2024-09-12
  • Online Date：2025-11-07
  • Published：2025-03-22
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  • Received：2024-09-12
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    Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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