PDF
Full
Outline
OBJECTIVE To prepare, characterize, and investigate the transdermal behavior of methotrexate phospholipid complex organogel (MTX-PC/OG). METHODS The solubility of MTX-PC in the oil phase, lowest gelling concentration, phase transition temperature, and stability were evaluated as criteria. Preliminary screening of oil phase types, gelling agents, and types and amounts of cogelators for MTX-PC/OG was carried out. The effects of oil phase type, cogelator type and dosage on the transdermal behavior of MTX-PC in vitro were investigated by modified Franz diffusion cell method. The appearance, viscosity, phase transition temperature, content and rheological properties of MTX-PC/OG were characterized. RESULTS Medium chain triglyceride (MCT), isopropyl myristate (IPM) and ethyl oleate (EO) exhibited favorable solubility for MTX-PC. Glycerin monostearate (GMS) demonstrated the most robust gelling capacity as a gelling agent, with optimal gel spreading at a 12.5% concentration. In vitro transdermal permeation results indicated that using MCT as the oil phase and Span 20 as the cogelator significantly enhanced MTX permeation and retention. MTX-PC/OG appeared as a light yellow semisolid state with a uniform texture, viscosity of (85.9±0.5) Pa·s, and a phase transition temperature of (50.4±0.5) ℃. Rheological assessments revealed that MTX-PC/OG is a pseudoplastic fluid with shear-thinning effects, suitable for transdermal drug delivery. Rheological assessments revealed that MTX-PC/OG is a pseudoplastic fluid with shear-thinning effects that facilitate its easy spread. CONCLUSION MTX-PC/OG prescription process is reasonable, with good transdermal and rheological behavior, making it well-suited for skin topical drug delivery.
PDF
241
117
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
