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OBJECTIVE To investigate the effect of this tratitional Chinese medicine irradiation sterilization on the chemical composition, especially pills with complex herb composition. METHODS The chemical composition of Pishenliangzhu Pills was examined using high-resolution mass spectrometry. Then, the obtained data were used for the multivariate statistical analysis of the components of Pishenliangzhu Pills and finally, the contents of 22 index components of 15 medicines in the Chinese Pharmacopoeia 2020 were compared before and after irradiation, and the rest of the compounds were analyzed by mass spectrometry, so as to comprehensively investigate the differences in the chemistry of the irradiated sterilizers.RESULTS A total of 260 compounds were identified,including 45 flavonoids, 28 triterpenoids, 24 phenylpropanoid compounds, and 163 glycosides, organic acids, lipids, amino acids, and alkaloids.Principal component analysis and cluster analysis revealed that there were no significant changes in the chemical composition of Pishenliangzhu Pills after Cobalt-60 irradiation at a dose of(2.5±0.5)kGy, with only 13 components showing minor alterations.CONCLUSION This study demonstrates the potential of high-resolution mass spectrometry in investigating chemical differences induced by irradiation sterilization in traditional Chinese medicine using Pishenliangzhu Pills as an example, which providing scientific evidence for the utilization of irradiation sterilization technology in producing Chinese patent medicines.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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