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Determination Method of the dn/dc of Sodium Hyaluronate
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Lirong ZHANG1, 2, Yujuan SONG2, Jing LI2, Huihong FAN2, Yue WANG2, *, Bo LIU2, *
Chinese Pharmaceutical Journal | 2025, 60(4) : 407 - 411
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Chinese Pharmaceutical Journal | 2025, 60(4): 407-411
Determination Method of the dn/dc of Sodium Hyaluronate
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Lirong ZHANG1, 2, Yujuan SONG2, Jing LI2, Huihong FAN2, Yue WANG2, *, Bo LIU2, *
Affiliations
  • 1 School of Pharmacy, Yantai University, Yantai 264003, China
  • 2 NMPA Key Laboratory for Quality Research and Evaluation of Chemical Drugs, National Institutes for Food and Drug Control, Beijing 102629, China
Published: 2025-02-22 doi: 10.11669/cpj.2025.04.010
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OBJECTIVE To establish a universal method for determining the refractive index increment(dn/dc)of sodium hyaluronate(SH),laying the foundation for achieving accurate determination of SH molecular weight and molecular weight distribution. METHODS Various instruments, mobile phases,and samples were used to study the dn/dc of SH. RESULTS SH was more stable in 0.1 mol·L-1 sodium nitrate solution,and the relative standard deviation(RSD)of dn/dc was less than 1.0%(n=3). CONCLUSION The newly established determination method is simple,fast,and accurate,solving the problem of difficult determination of SH dn/dc both domestically and internationally for many years.It also provides new methods and ideas for determining the dn/dc of other polymer substances.

sodium hyaluronate  /  molecular mass  /  size exclusion chromatography-multi angle laser light scattering(SEC-MALLS)  /  refractive index increment(dn/dc)  /  Calypso Ⅱ composition-gradient system
Lirong ZHANG, Yujuan SONG, Jing LI, Huihong FAN, Yue WANG, Bo LIU. Determination Method of the dn/dc of Sodium Hyaluronate[J]. Chinese Pharmaceutical Journal, 2025 , 60 (4) : 407 -411 . DOI: 10.11669/cpj.2025.04.010
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Year 2025 volume 60 Issue 4
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doi: 10.11669/cpj.2025.04.010
  • Receive Date：2024-08-13
  • Online Date：2025-11-07
  • Published：2025-02-22
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  • Received：2024-08-13
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    1 School of Pharmacy, Yantai University, Yantai 264003, China
    2 NMPA Key Laboratory for Quality Research and Evaluation of Chemical Drugs, National Institutes for Food and Drug Control, Beijing 102629, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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