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Preparation of Albumin Modified Liposomes Based on Paclitaxel Prodrug and Study on Their Antitumor Activity in Vitro and in Vivo
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Jianjun GE1, 3, Yuanyuan LI3, Hongyong CHE2, Fang CHEN3, Haoxin LI3, Lingbing LI3, *
Chinese Pharmaceutical Journal | 2025, 60(4) : 384 - 393
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Chinese Pharmaceutical Journal | 2025, 60(4): 384-393
Preparation of Albumin Modified Liposomes Based on Paclitaxel Prodrug and Study on Their Antitumor Activity in Vitro and in Vivo
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Jianjun GE1, 3, Yuanyuan LI3, Hongyong CHE2, Fang CHEN3, Haoxin LI3, Lingbing LI3, *
Affiliations
  • 1 Zaozhuang Vocational College of Science and Technology, Zaozhuang 277500, China
  • 2 Yantai Food and Drug Inspection and Testing Center, Yantai 264035, China
  • 3 Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Published: 2025-02-22 doi: 10.11669/cpj.2025.04.008
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OBJECTIVE To prepare human serum albumin(HSA) modified liposomes,realize thetargeting ability bybinding to albumin receptor and achieve targeting transportto tumor tissues. METHODS The paclitaxel-maleimide prodrug was synthesized, and the prodrug loaded liposomes were constructed based on it. Then, albumin modified liposomes were prepared by spontaneous binding between maleimide and free mercapto group in albumin structure, and their pharmacological properties were characterized. Moreover, cell and animal experiments were conducted to further investigate the uptake ability of albumin modified liposomes by tumor cells, as well as its anti-tumor activity and targeting in vivo. RESULTS The cell uptake of albumin-modified liposomes mediated by overexpression of albumin-binding protein on tumor cell surface was significantly increased. The cell intake of coumarin-6 loaded albumin-modified liposomes was significantly higher than that of free coumarin-6. The evaluation of antitumor activity in vivo showed that the PTX@HSA-lipos group had a better effect on tumor volume control. After administration, the average tumor weight in the saline group was(7.88±1.22) g, and that in the PTX@HSA-lipos group was (3.126±0.68)g, with significant difference(F=28.36, P<0.05). CONCLUSION Albumin modified liposomes are a kind of drug delivery system with high efficiency, low toxicity and targeting to tumor tissue.

liposome  /  human serum albumin modified  /  prodrug  /  paclitaxel  /  tumor targeting
Jianjun GE, Yuanyuan LI, Hongyong CHE, Fang CHEN, Haoxin LI, Lingbing LI. Preparation of Albumin Modified Liposomes Based on Paclitaxel Prodrug and Study on Their Antitumor Activity in Vitro and in Vivo[J]. Chinese Pharmaceutical Journal, 2025 , 60 (4) : 384 -393 . DOI: 10.11669/cpj.2025.04.008
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Year 2025 volume 60 Issue 4
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doi: 10.11669/cpj.2025.04.008
  • Receive Date：2023-05-08
  • Online Date：2025-11-07
  • Published：2025-02-22
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  • Received：2023-05-08
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Affiliations
    1 Zaozhuang Vocational College of Science and Technology, Zaozhuang 277500, China
    2 Yantai Food and Drug Inspection and Testing Center, Yantai 264035, China
    3 Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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