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The concept of entropy is originated from physics which represents a degree of disorder. Entropy increase is a natural law for extinction of things. In the field of life science, entropy could be used to measure the quality of life. Organisms utilize their inherent negative entropy mechanisms of self-organization, defense, self-healing, wear resistance, and adaptability to counteract entropy increase, and thus to cure various diseases and curb aging processes, while maintaining optimal health. As an external intervention, good drugs could trigger negative entropy mechanisms by enhancing one or more of the above machineries, thus assist the body to recover. This article explores the potential applications of biological entropy in drug discovery research, aiming to leverage its power in the future for a good understanding of drug targets, elucidation of drug mechanisms, rational design of novel drugs and rigorous evaluation of drug efficacy, especially pertinent to multi-target drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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