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OBJECTIVE To explore the occurrence and characteristics of remdesivir-related bradyarrhythmia and provide references for clinical safe drug use. METHODS The case reports of remdesivir-related bradyarrhythmia published in PubMed, Embase, CNKI, Wanfang and VIP were searched from the establishment of each database to October 2023, and statistical analysis was conducted on relevant information and data. RESULTS A total of 32 cases from 23 articles were identified and included in the analysis. There were 16 males (50.0%) and 14 females (43.8%), aged from 3 months to 80 years, with an average age of (43.1±23.5) years. Twenty-seven patients (84.4%) experienced bradyarrhythmia within 3 days after medication. When bradyarrhythmia occurred, the heart rate decreased by 25.0% to 76.0% from baseline, and 20 patients (62.5%) presented with severe bradyarrhythmia. After withdrawal or continuation of treatment and symptomatic management such as atropine or cardiac pacing, all patients had a good outcome except for 2 cases (6.3%) who eventually died from exacerbation of the primary disease. CONCLUSIONS Clinical monitoring of the patient's heart rate should be strengthened during the use of remdesivir, especially in the first 3 days after medication. Once bradyarrhythmia is found, the patient's condition should be comprehensively considered to decide whether to stop remdesivir, and atropine or cardiac pacing can be inserted if necessary.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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