PDF
Full
Outline
Hydrogels and nanoparticles have great application prospects in drug delivery. Hydrogels possess good biocompatibility and physicochemical versatility to enable disease-triggered in situ self-assemble and sustained or stimuli-responsive drug release. The high targeting ability and low toxicity of nanoparticles can significantly improve the delivery efficiency of antitumor drugs. However, hydrogels and nanoparticles still face many challenges in their applications, for example, hydrogels suffer from low mechanical strength and have difficulty in delivering hydrophobic drugs, while nanoparticles have off-target effects and low accumulation and retention in tumors. Therefore, the incorporation of nanoparticles into the hydrogel network can form a novel multifunctional system that enables the hydrogel to serve as a reservoir for the local delivery of nano-drugs into tumors, thereby combining the advantages of two preparations to produce synergistic therapeutic effects. Herein, we review the design of drug release behavior of nanoparticle-hydrogel composite systems, and outline the recent progress of nanoparticle-hydrogel composite systems in the local application of antitumor drugs, including intratumoral and peritumoral injections, subcutaneous or intramuscular injections, transdermal administration and intraluminal administration, providing insights and references for the rational design of novel anti-tumor dosage forms and preparations.
PDF
191
91
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
