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Research progress for controlled release mechanism of smart drug carrier
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Yue-yue FAN1, 2, Wen-yan HAO2, Sha-sha ZHANG3, Yang YANG2, Chun-sheng GAO1, 2
Chinese Journal of New Drugs | 2021, 30(21) : 1982 - 1989
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Chinese Journal of New Drugs | 2021, 30(21): 1982-1989
Research progress for controlled release mechanism of smart drug carrier
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Yue-yue FAN1, 2, Wen-yan HAO2, Sha-sha ZHANG3, Yang YANG2, Chun-sheng GAO1, 2
Affiliations
  • 1College of Pharmacy, Henan University, Kaifeng 475000, China
  • 2Department of Pharmaceutics, Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
  • 3The First Affiliated Hospital of Jiamusi University, Jiamusi 154003, China
Published: 2021-11-15
Outline
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Smart drug carriers with a unique stimulus-response mechanism can respond to changes in physical and chemical properties under the stimulation of exogenous or human body's own environmental factors, and thus can control the delivery site of the drug, and automatically adjust the drug release rate. Currently, it has become one of the research hotspots in the field of materials science and pharmacy. Due to the advantages of improving the bioavailability of drugs in the body and reducing their side effects, smart drug carriers will play an increasingly important role in future clinical treatments. This article reviews the latest research progress in the mechanism of action, material properties and potential applications of stimulus-responsive smart drug carriers for different stimuli, and further prospects for their development.

smart drug delivery systems  /  smart drug carrier  /  drug release stimulus  /  stimulus response mechanism  /  controlled release mechanism
范月月, 郝文艳, 张沙莎, 杨阳, 高春生. “智能型”药物载体调释新机制研究进展. 中国新药杂志, 2021 , 30 (21) : 1982 -1989 .
Yue-yue FAN, Wen-yan HAO, Sha-sha ZHANG, Yang YANG, Chun-sheng GAO. Research progress for controlled release mechanism of smart drug carrier[J]. Chinese Journal of New Drugs, 2021 , 30 (21) : 1982 -1989 .
Year 2021 volume 30 Issue 21
30
6
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  • Online Date:2026-10-30
  • Published:2021-11-15
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  • Accepted:2021-04-20
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Affiliations
    1College of Pharmacy, Henan University, Kaifeng 475000, China
    2Department of Pharmaceutics, Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
    3The First Affiliated Hospital of Jiamusi University, Jiamusi 154003, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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