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Application of high content analysis in the study of toxicity mechanism of drug mitochondrial damage
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Jia-min SONG1, Meng WANG1, Mei-ling CHEN2
Chinese Journal of New Drugs | 2021, 30(20) : 1861 - 1866
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收藏切换
Chinese Journal of New Drugs | 2021, 30(20): 1861-1866
Application of high content analysis in the study of toxicity mechanism of drug mitochondrial damage
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Jia-min SONG1, Meng WANG1, Mei-ling CHEN2
Affiliations
  • 1Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-based Chinese Medicine, Tianjin 301617, China
  • 2Tianjin University of Traditional Chinese Medicine School of Chinese Materia Medica, Tianjin 301617, China
Published: 2021-10-30
Outline
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High content technology is a kind of cell imaging technology, which can obtain many parameters of cells simultaneously by using its automatic microscope, fluorescence probe and image analysis system. It has the advantages of high efficiency, high speed and multi index, and has been gradually used in the analysis and screening of various drug cytotoxicity. This paper reviews the application of high content technology in the study of mitochondrial damage mechanism of liver, kidney, nerve and other tissues in recent years, aiming to provide reference for further drug toxicity research and safe drug use.

high content analysis  /  high content screening  /  drug toxicity  /  mitochondrial damage  /  mechanisms of toxicity
宋佳敏, 王萌, 陈美玲. 高内涵技术在药物线粒体损伤毒性机制研究中的应用. 中国新药杂志, 2021 , 30 (20) : 1861 -1866 .
Jia-min SONG, Meng WANG, Mei-ling CHEN. Application of high content analysis in the study of toxicity mechanism of drug mitochondrial damage[J]. Chinese Journal of New Drugs, 2021 , 30 (20) : 1861 -1866 .
Year 2021 volume 30 Issue 20
26
5
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  • Online Date:2026-10-30
  • Published:2021-10-30
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  • Accepted:2021-06-25
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    1Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-based Chinese Medicine, Tianjin 301617, China
    2Tianjin University of Traditional Chinese Medicine School of Chinese Materia Medica, Tianjin 301617, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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