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Rivaroxaban-induced bleeding: analysis of literature in China and abroad
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Xue SUN, Cai-hui GUO, Hao-jing SONG, Zhan-jun DONG
Chinese Journal of New Drugs | 2021, 30(21) : 2003 - 2008
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Chinese Journal of New Drugs | 2021, 30(21): 2003-2008
Rivaroxaban-induced bleeding: analysis of literature in China and abroad
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Xue SUN, Cai-hui GUO, Hao-jing SONG, Zhan-jun DONG
Affiliations
  • The Pharmaceutical Department of Hebei General Hospital, Shijiazhuang 050051, China
Published: 2021-11-15
Outline
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Objective:

To analyze the occurrence and clinical characteristics of bleeding induced by rivaroxaban in order to provide reference for clinical medication.

Methods:

Bleeding adverse reaction literature from CNKI, VIP, Chinese Hospital Data Library, Wanfang, PubMed and EMBase since the listing of rivaroxaban were collected and analyzed.

Results:

A total of 51 effective literature of report cases regarding bleeding ADR induced by rivaroxaban, involving 59 patients, were identified and included in the analysis. The majority of patients were over 60 years old (51 cases, 86.44%). Most of bleeding occurred within 30 days after medication (27 cases, 45.76%). Cerebral hemorrhage was commonly seen (15 cases, 25.42%). Conventional treatment is mostly applied (26 cases, 44.07%). In terms of treatment outcome, most bleeding stopped within 1 to 7 days (29 cases, 49.15%). There were 6 deaths, the majority of which occurred within 14 days of admission (5 cases, 83.33%).

Conclusion:

The bleeding ADR induced by rivaroxaban need to be highly valued in clinical, and drug monitoring need to be strengthened to reduce the occurrence of fatal bleeding ADR.

rivaroxaban  /  bleeding  /  adverse drug reactions  /  literature analysis
孙雪, 郭彩会, 宋浩静, 董占军. 利伐沙班致出血不良反应的国内外文献分析. 中国新药杂志, 2021 , 30 (21) : 2003 -2008 .
Xue SUN, Cai-hui GUO, Hao-jing SONG, Zhan-jun DONG. Rivaroxaban-induced bleeding: analysis of literature in China and abroad[J]. Chinese Journal of New Drugs, 2021 , 30 (21) : 2003 -2008 .
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  • Online Date：2026-10-30
  • Published：2021-11-15
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  • Accepted：2021-03-19
Affiliations
    The Pharmaceutical Department of Hebei General Hospital, Shijiazhuang 050051, China
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