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Analysis of withdrawal outcomes of 32 patients with melanoma in clinical trials
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Dan LI1, Yan ZHANG2, Dong-qing LU1, Kang JIAN1
Chinese Journal of New Drugs | 2021, 30(20) : 1911 - 1914
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Chinese Journal of New Drugs | 2021, 30(20): 1911-1914
Analysis of withdrawal outcomes of 32 patients with melanoma in clinical trials
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Dan LI1, Yan ZHANG2, Dong-qing LU1, Kang JIAN1
Affiliations
  • 1Peking University Cancer Hospital National Drug Clinical Trial Center, Beijing Institute for Cancer Research, Beijing 100142, China
  • 2Peking University Cancer Hospital Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Cancer Center, Beijing 100142, China
Published: 2021-10-30
Outline
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Objective:

To analyze the information of clinical trial subjects who stopped taking drugs during the epidemic period, so as to provide guidance for the follow-up of clinical trial subjects under special events.

Methods:

The data of subjects in clinical trials of melanoma who stopped treatment during the epidemic period from February 3, 2020 to May 29, 2020 were collected. SPSS 24.0 statistical analysis software was used to compare the general data and clinical trial information between patients with advanced disease and patients without disease progression.

Results:

A total of 32 subjects were included, including 15 progressive subjects and 17 non progressing subjects. Gender, primary site, enrollment test, previous treatment, recurrence and metastasis site, best evaluation during enrollment, and administration regimen were independent risk factors for disease-free progression (P<0.05). There was significant difference in the number of medication cycles between the two groups.

Conclusion:

The previous best efficacy, medication regimen, and number of medication cycles have significant effects on the outcome of cancer clinical trials under special public health events.

melanoma  /  clinical trial  /  subjects  /  drug withdrawal
李丹, 张燕, 卢冬青, 见康. 32例黑色素瘤临床试验受试者的停药结局分析. 中国新药杂志, 2021 , 30 (20) : 1911 -1914 .
Dan LI, Yan ZHANG, Dong-qing LU, Kang JIAN. Analysis of withdrawal outcomes of 32 patients with melanoma in clinical trials[J]. Chinese Journal of New Drugs, 2021 , 30 (20) : 1911 -1914 .
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Year 2021 volume 30 Issue 20
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  • Online Date：2026-10-30
  • Published：2021-10-30
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  • Accepted：2021-05-09
Affiliations
    1Peking University Cancer Hospital National Drug Clinical Trial Center, Beijing Institute for Cancer Research, Beijing 100142, China
    2Peking University Cancer Hospital Key Laboratory of Carcinogenesis and Translational Research, Gastrointestinal Cancer Center, Beijing 100142, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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