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Outline
To compare the lipid-regulating effects of long gypenosides and gypenosides.
Ninety male rats were randomly divided into control group, model group, positive group (1 mg·kg-1), gypenosides groups (60, 30 and 15 mg·kg-1) and long gypenosides groups (60, 30 and 15 mg·kg-1). The hyperlipidemia model was established by feeding high-fat diets, then all rats were intervened with corresponding medicines for 6 weeks. The body weight, liver index, levels of blood lipid, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. HE staining was conducted to evaluate the histopathological changes of livers.
Compared with the control group, the body weight, liver index, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ALT and AST in the model group were significantly increased. The high-density lipoprotein cholesterol (HDL-C) level was significantly decreased. Fatty degeneration was obviously observed in liver tissue. Compared with the model group, gypenosides significantly decreased TC and ALT levels in serum. Long gypenosides significantly reduced the levels of TC, TG, AST and ALT, increased the level of HDL-C. High dose long gypenosides and gypenosides relieved the fatty degeneration. The results of correlation analysis showed that the levels of TC, TG and AST in serum correlated with plant origin.
Long gypenosides and gypenosides can reduce blood lipid and have positive effect on liver tissue of hyperlipidemia rats, especially long gypenosides.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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