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Research and development progress of SARS-CoV-2 neutralizing antibody
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Xin YUE1, 2, Yong-bing PAN1, 2, Xiao-ming YANG2, 3
Chinese Journal of New Drugs | 2021, 30(19) : 1752 - 1758
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Chinese Journal of New Drugs | 2021, 30(19): 1752-1758
Research and development progress of SARS-CoV-2 neutralizing antibody
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Xin YUE1, 2, Yong-bing PAN1, 2, Xiao-ming YANG2, 3
Affiliations
  • 1Wuhan Institute of Biological Products, Wuhan 430207, China
  • 2National Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China
  • 3China National Biotec Group Company Limited, Beijing 100029, China
Published: 2021-10-15
Outline
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has widely spread around the world, exerting great impacts on economic growth and human life. It is the highest priority to develop safe and effective drugs. Neutralizing antibodies have achieved good results in previous clinical applications of some viral infectious diseases. They can be used not only for the short-term prevention of SARS-COV-2 infection, but also for the treatment of corona virus disease 2019 (COVID-19), showing important application value. At present, the research and development of SARS-CoV-2 neutralizing antibody has made its rapid progress in China and abroad. Many antibody drugs have entered clinical trials and been put into emergency use. This article mainly summarizes targets of SARS-CoV-2 neutralizing antibody, screening technologies, drug development progresses and problems to be concerned.

SARS-CoV-2  /  neutralizing antibody  /  clinical trial  /  immune escape
乐鑫, 潘勇兵, 杨晓明. 新型冠状病毒中和抗体的研发进展. 中国新药杂志, 2021 , 30 (19) : 1752 -1758 .
Xin YUE, Yong-bing PAN, Xiao-ming YANG. Research and development progress of SARS-CoV-2 neutralizing antibody[J]. Chinese Journal of New Drugs, 2021 , 30 (19) : 1752 -1758 .
Year 2021 volume 30 Issue 19
27
4
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  • Online Date:2026-10-30
  • Published:2021-10-15
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  • Accepted:2021-09-06
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    1Wuhan Institute of Biological Products, Wuhan 430207, China
    2National Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China
    3China National Biotec Group Company Limited, Beijing 100029, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
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Percentage of
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属
Genus
种数
Number of
species
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Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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