Full
Outline
Apoliprotein B mRNA-editing enzyme catalytic polypetide protein (A3G) is a member of the innate immune family. It has cytosine deaminase activity and can be packaged into progeny viruses through interaction with Gag protein or the nucleocapsid domain of viral RNA. In the process of HIV-1 reverse transcription, A3G deaminates cytosine and introduces uracil into the minus strand of DNA, resulting in excessive mutation of the virus and exerting antiviral effects. In addition, A3G plays an anti-HIV-1 role by packaging itself into virions. HIV-1 co-regulatory protein Vif can antagonize A3G inhibition of HIV-1 through the ubiquitin-proteasome system. Therefore, up-regulating the expression of A3G or inhibiting the antagonistic effect of Vif on A3G may become a new effective method for the treatment of HIV-1 infection.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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