Full
Outline
To confirm the efficacy of human rabies immunoglobulin (HRIG).
Animal experiments was used to show the protection effect of the neutralizing antibody contained in HRIG on living animals to neutralize rabies virus in vivo. The function of neutralizing antibody contained in HRIG to neutralize and protect cells was evaluated by cytology experiments in vitro.
The survival rate of mice was 0 in 0.006 and 0.003 IU·mL-1 groups, 16.7% in 0.012 IU·mL-1 group, 41.7% in 0.024 IU·mL-1 group, 75.0% in 0.048 IU·mL-1 group, and 100% in 0.095, 0.190 and 0.380 IU·mL-1 groups. The inhibition rate of virus-infected cells was 100% in 0.317 and 0.951 IU·mL-1, 99% in 0.106 IU·mL-1, 58% in 0.035 IU·mL-1, close to 0 in 0.012 IU·mL-1. The degree of HRIG reducing viral infectivity decreases as the concentration of neutralizing antibodies decreasing.
HRIG can neutralize the virus effectively in vivo and in vitro, and has a good dose-response relationship.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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