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In recent years, increasing number of oncolytic virus drugs have entered clinical study. Administration approach mainly involves intratumoral, intravenous, intracranial intra-arberial, and so on. Among them, indications for intraperitoneal administration of oncolytic virus mostly include malignant pleural effusion, malignant pleural mesothelioma, and thoracic/abdominal cancer. Due to the inherent characteristics of the administration approach, the absorption of intra-cavity administration is slower than that by intravenous, and the pleural injection requires an indwelling catheter. The efficacy of intraperitoneal administration greatly varies among different oncolytic virus products and indications. Among them, pleural administration for malignant pleural effusion shows good efficacy, while the efficacy of intra-cavity administration for malignant pleural mesothelioma and ovarian cancer is unclear. Due to limited participants in relevant clinical study, the safety and efficacy need further verification by confirming clinical trials.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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