Full
Outline
Personalized peptide therapeutic tumor vaccine is a kind of precision medical product prepared according to the tumor heterogeneity and human leukocyte antigen heterogeneity in patients. It has strong anti-tumor specificity, low toxic and side effects, definite antigen sequence, and is easy to be prepared and controlled. Additionally, the economic cost is relatively low. This kind of vaccine has become a hot spot in tumor vaccine development. This paper analyzes and summarizes the Ⅰ~Ⅲ phase clinical pharmacodynamics researches of personalized tumor-associated antigen peptide therapeutic tumor vaccines and personalized tumor neoantigen peptide therapeutic tumor vaccines in the recent 2 decades, in order to provide a reference for the development and evaluation of such vaccines. At present, the specific humoral and cellular immune response rates of patients vaccinated with personalized tumor-associated peptide therapeutic tumor vaccines are about 70% and 60%, respectively. The specific cellular immune response can be induced in patients by about 60% of the neoantigens in personalized tumor neoantigen peptide therapeutic tumor vaccines. The most common adverse reaction of the two types of vaccines was skin reaction at the injection site, both of which generally had good immunogenicity and tolerability.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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