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Pharmacokinetic research strategy of ophthalmic drugs
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Shuo SONG1, 2, Ruo-nan WANG1, 2, Yi-min QIAN2, Yong MENG3, Lu ZHOU3, Hua LI2, 3
Chinese Journal of New Drugs | 2021, 30(18) : 1668 - 1674
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Chinese Journal of New Drugs | 2021, 30(18): 1668-1674
Pharmacokinetic research strategy of ophthalmic drugs
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Shuo SONG1, 2, Ruo-nan WANG1, 2, Yi-min QIAN2, Yong MENG3, Lu ZHOU3, Hua LI2, 3
Affiliations
  • 1National Shanghai Center for New Drug Safety Evaluation and Research of China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 2Shanghai InnoStar Biotech Co., Ltd., Shanghai 201203, China
  • 3InnoStar Biotech Nantong Co., Ltd., Nantong 226133, China
Published: 2021-09-30
Outline
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Ocular pharmacokinetics is the process of absorption, distribution, metabolism and excretion of drugs in eye tissues, and can be quantitatively described by mathematical models, which is more sophisticated and complex than the overall pharmacokinetics. Ocular pharmacokinetics research is the key to the development of ophthalmic drugs and to guide the rational use of ophthalmic drugs. Therefore, a comprehensive understanding of the research content of ocular pharmacokinetics is very important for ophthalmic drugs developers and users. This article outlines the key content of ocular pharmacokinetic research, so that relevant ophthalmologists can have an overall understanding of the pharmacokinetics of ophthalmic drugs, and improve the safety and rationality of ophthalmic drugs.

barrier  /  administration route  /  ocular pharmacokinetics
宋硕, 王若男, 钱仪敏, 孟永, 周璐, 李华. 眼科药物的药动学研究策略. 中国新药杂志, 2021 , 30 (18) : 1668 -1674 .
Shuo SONG, Ruo-nan WANG, Yi-min QIAN, Yong MENG, Lu ZHOU, Hua LI. Pharmacokinetic research strategy of ophthalmic drugs[J]. Chinese Journal of New Drugs, 2021 , 30 (18) : 1668 -1674 .
Year 2021 volume 30 Issue 18
17
2
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  • Online Date:2026-10-30
  • Published:2021-09-30
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  • Accepted:2021-06-21
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Affiliations
    1National Shanghai Center for New Drug Safety Evaluation and Research of China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    2Shanghai InnoStar Biotech Co., Ltd., Shanghai 201203, China
    3InnoStar Biotech Nantong Co., Ltd., Nantong 226133, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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