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Pharmacokinetic investigation of berberine dernivative WZX20 in rats
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Gao-feng ZHU1, 2, Rui CHEN2, Yi-ming ZHANG3, Kai-hong ZHU3, Jian-ta WANG3, Lei TANG2
Chinese Journal of New Drugs | 2021, 30(18) : 1703 - 1708
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Chinese Journal of New Drugs | 2021, 30(18): 1703-1708
Pharmacokinetic investigation of berberine dernivative WZX20 in rats
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Gao-feng ZHU1, 2, Rui CHEN2, Yi-ming ZHANG3, Kai-hong ZHU3, Jian-ta WANG3, Lei TANG2
Affiliations
  • 1School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China
  • 2Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guiyang 550025, China
  • 3School of Pharmacy, Guizhou Medical University, Guiyang 550025, China
Published: 2021-09-30
Outline
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Objective:

To study the pharmacokinetics of berberine dernivative WZX20 in rats.

Methods:

SD rats were intragastrically (ig) or intravenously (iv) given WZX20, and plasma were collected after injection. WZX20 components in plasma were determined by LC-MS. Pharmacokinetic parameters were determined from the plasma concentration-time data with DAS software package.

Results:

The pharmacokinetic parameters after gastric lavage were as follows: AUC0→t (596.46±22.22) ng·h·mL-1; AUC0-∞ (607.59±23.51) ng·h·mL-1; t1/2 (1.76±0.15) h; CL (32.96±1.3) L·h·kg-1; Vd (83.62±7.54) L·kg-1; Cmax (172.98±13.51) ng·mL-1; Tmax (0.5) h; F=33.19%. The intravenous pharmacokinetics parameters were as follows: AUC0→t (177.61±30.52) ng·h·mL-1; AUC0→∞(183.08±30.90) ng·h·mL-1; t1/2 (1.74±0.17) h; CL (11.23±2.18) L·h·kg-1; Vd (25.17±6.81) L·kg-1.

Conclusion:

The established LC-Ms method is accurate, sensitive and rapid, and can be used for the blood concentration determination of WZX20. The pharmacokinetic parameters of WZX20 provide a good foundation for the study on the druggability of WZX20.

berberine  /  derivatives  /  pharmacokinetics  /  bioavailability  /  LC-MS
朱高峰, 陈瑞, 张倚鸣, 朱开红, 王建塔, 汤磊. 黄连素衍生物WZX20在大鼠体内的药动学研究. 中国新药杂志, 2021 , 30 (18) : 1703 -1708 .
Gao-feng ZHU, Rui CHEN, Yi-ming ZHANG, Kai-hong ZHU, Jian-ta WANG, Lei TANG. Pharmacokinetic investigation of berberine dernivative WZX20 in rats[J]. Chinese Journal of New Drugs, 2021 , 30 (18) : 1703 -1708 .
Appendix
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Year 2021 volume 30 Issue 18
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Article Info
  • Online Date：2026-10-30
  • Published：2021-09-30
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History
  • Accepted：2021-02-24
Funding
Affiliations
    1School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China
    2Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guiyang 550025, China
    3School of Pharmacy, Guizhou Medical University, Guiyang 550025, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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