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Outline
To investigate the hypolipidemic activity of Tibet medicine “Malus Fructus”.
The hypolipidemic activity of Malus Fructus was studied by using two kinds of hyperlipidemia models: in vitro (hyperlipidemia cell model induced by medical fat milk) and in vivo (hyperlipidemia mouse model induced by high fat feed). At the same time, by comparing the effects of same dose of Malus Fructus, Malus Folium, hawthorn on the body weight, viscera index, blood levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and glutamic oxaloacetic transaminase (AST) of high fat mice, the blood lipid-lowering effect of Malus Fructus was evaluated.
In the model of hyperlipidemia induced by medical fat milk, the levels of TC and TG in steato-degeneration cells were significantly decreased by the administration of Malus Fructus (50, 100 μg·mL-1), and it obviously improved the morphology of steato-degeneration cells. In the mouse model of hyperlipidemia induced by high-fat diet, the administration of Malus Fructus (0.75, 1.5 g·kg-1,ig) slowed down the weight gain of high-fat mice, significantly reduced the liver index and TC, TG, LDL-C, ALT, AST levels, and increased HDL-C levels. Under the same dose, the effects of reducing TC of different materials ranked in the following sequence: hawthorn > Malus Fructus > Malus Folium; the effects of lowering TG, LDL-C and ALT were as follows: Malus Fructus > hawthorn > Malus Folium; AST lowering effect: Malus Fructus > Malus Folium > hawthorn; HDL-C increasing effect: Malus Folium > Malus Fructus > hawthorn.
Malus Fructus has good activity of lowering blood lipid, which can significantly decrease blood lipid level, relieve obesity symptoms caused by high-fat diet, and alleviate liver injury. In addition, it is better than Malus Folium and hawthorn in lowering TG, LDL-C and ALT.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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