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Application progress of PET in the study of drug addiction mechanism
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Shu-zhe WANG1, 2, Yan WANG2, Fang-hua HUANG3, Yun-liang QIU2
Chinese Journal of New Drugs | 2021, 30(18) : 1661 - 1667
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Chinese Journal of New Drugs | 2021, 30(18): 1661-1667
Application progress of PET in the study of drug addiction mechanism
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Shu-zhe WANG1, 2, Yan WANG2, Fang-hua HUANG3, Yun-liang QIU2
Affiliations
  • 1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
  • 2National Shanghai Center for New Drug Safety Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 3Center for Drug Evaluation, National Medical Products Administration, Beijing 100038, China
Published: 2021-09-30
Outline
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Drug addiction is one of the most serious public health problems in the world. At present, drug addiction is considered as a chronic and recurrent brain disease. The exact mechanism of drug addiction has not been fully elucidated. The development of peddler imaging technology and the synthesis of various imaging agents have provided great help for people to understand the neuropharmacological mechanism of drug addiction. This paper reviews the application of positron emission tomography (PET) imaging in the study of drug addiction mechanism, focusing on the monitoring of neurotransmitter receptors, receptor transporters, regional cerebral blood flow and cerebral glucose metabolism in the process of drug addiction by using PET in vivo imaging technology, so as to understand the neurobiological basis of drug addiction and provide theoretical basis for effective treatment measures.

drug addiction  /  mechanism  /  positron emission computed tomography  /  imaging agent
王舒哲, 王雁, 黄芳华, 邱云良. 正电子发射计算机断层显像技术在药物成瘾机制研究中的应用进展. 中国新药杂志, 2021 , 30 (18) : 1661 -1667 .
Shu-zhe WANG, Yan WANG, Fang-hua HUANG, Yun-liang QIU. Application progress of PET in the study of drug addiction mechanism[J]. Chinese Journal of New Drugs, 2021 , 30 (18) : 1661 -1667 .
Year 2021 volume 30 Issue 18
20
4
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  • Online Date:2026-10-30
  • Published:2021-09-30
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  • Accepted:2021-06-24
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Affiliations
    1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
    2National Shanghai Center for New Drug Safety Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    3Center for Drug Evaluation, National Medical Products Administration, Beijing 100038, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
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Percentage of
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Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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