Full
Outline
Glucagon-like peptide-1 (GLP-1), considered as an effective peptide for the treatment of diabetes, can stimulate insulin secretion in response to rising glucose. Moreover, the novel peptide is becoming a new choice to treat type II diabetes. Nevertheless, the half-life of GLP-1 (approximately 1~2 min) is short, limiting its clinical application in diabetes. GLP-1-loaded PLGA microspheres have drawn more attentions in recent years. In this article, we introduces the preparation methods for encapsulation of GLP-1 in preparing PLGA microspheres. In order to solve the shortcomings of large burst release and drug degradation of traditional microspheres, some novel microsphere formulations (double-wall microspheres, self-healing microspheres and other new formulations of microspheres) are summarized. The new formulations effectively enhance protein stability and long-acting efficiency is achieved, providing new strategies for developing protein-loaded microspheres.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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