Full
Outline
Universal CAR-T cell technology belongs to the universal T cell technology based on gene editing in general CAR-T. It knocks out the signal receptor factor of T cell through gene editing, and produces CAR-T cell by using modified T cell from healthy volunteers; therefore it will not cause immune rejection such as graft versus host disease (GvHD) and host versus graft reaction (HvGR) after infusion. In animal experiments and early clinical trials, UCAR-T technology shows significant anti-tumor effect, wide applicability and tremendous application potentials. In terms of industrialization, UCAR-T cell technology is expected to solve the problems of high cost in designing and culturing autologous CAR-T preparations, of long preparation cycle, difficult quality control, insufficient cell quantity and expansion capacity, because of its unique features such as quality controllable, off-the-shelf, and easy for large-scale preparation, etc. This paper introduces the current research progress and existing problems of UCAR-T cells, and conducts a preliminary analysis of the existing problems, providing a reference for the fundamental research and clinical trials of UCAR-T cells.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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