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Outline
To evaluate the analgesic and adverse effects of pregabalin after laparoscopic surgery.
Pubmed, Embase, Cochrane library, China Knowledge Network, Wanfang database and VIP database were searched for randomized controlled trials (RCT) that investigated pregabalin analgesa in adult patients undergoing laparoscopic surgery from inception to October 2019. RevMan 5.3 was used to perform analysis.
Eighteen RCTs with a total of 1169 subjects were included. Pregabalin was associated with a significant reduction in pain scores and opioid consumption at 24 h compared with placebo (MD=-8.34 mm, 95%CI: -11.68~-4.99, P<0.001 and MD=-5.88 mg, 95%CI: -7.66~-4.11, P<0.001). Patients receiving pregabalin had less postoperative nausea and vomiting compared with placebo (RR=0.75, 95%CI: 0.62~0.92, P=0.006). Visual disturbance was more common in pregabalin group compared with placebo group (RR=2.86, 95%CI: 1.33~6.18, P=0.007). There was no significant difference in the incidence of dizziness and sedation between the two groups (RR=1.08, 95%CI: 0.82~1.42, P=0.59; RR=2.41, 95%CI: 0.44~13.17, P=0.31).
Perioperative administration of pregabalin may decrease pain scores, opioid consumption, nausea and vomiting when used in different types of laparoscopic surgery. Single preoperative dose is recommended to reduce the occurrence of visual disturbance.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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