Full
Outline
To quantitatively evaluate the efficacy, safety, and economic characteristics of tofacitinib for the treatment of rheumatoid arthritis (RA) patients by using the method of health technology assessment (HTA) and to provide evidence for medication selection and decision making based on the actual application of tofacitinib in clinical practice.
The HTA reports, systematic reviews/Meta analyses, and pharmacoeconomic researches published before May 31, 2019 were systematically searched. The databases and websites we searched included HTA official websites, English databases (PubMed and the Cochrane Library), and Chinese databases such as China Knowledge Network (CNKI), Wanfang and Weipu.
No HTA reports, but 21 Meta-analyses and 3 economic studies were included in this study. The results show that tofacitinib alone or combined with methotrexate treatment can clearly improve the efficacy of ACR, HAQ scores and other indicators of patients with RA, while the incidence of adverse events such as severe infections did not significantly increase. It can bring higher quality of life to patients with lower cost.
Tofacitinib and biologics are similar in efficacy and safety, and can improve patient medication compliance with a lower cost.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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