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Dependency evaluation of synthetic cathinones and related mechanisms
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Huan ZHANG1, Bei-bei LI2, Yun-liang QIU1, 2
Chinese Journal of New Drugs | 2021, 30(5) : 403 - 410
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Chinese Journal of New Drugs | 2021, 30(5): 403-410
Dependency evaluation of synthetic cathinones and related mechanisms
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Huan ZHANG1, Bei-bei LI2, Yun-liang QIU1, 2
Affiliations
  • 1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
  • 2China State Institute of Pharmaceutical Industry, Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
Published: 2021-03-15
Outline
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At the beginning of the 21st century, a large number of synthetic cathinones flowed into the illegal market, which are sold as “bath salts” and “plant food” online, and usually labeled “not for human use”. There are a great variety of this kind of substance and they can be rapidly derived. The structures or pharmacological properties of synthetic cathinones are similar to cocaine or methamphetamine, thus they were often abused and had a great impact on personal health and social stability. In order to further evaluate the abuse potential of synthetic cathinones and its mechanism of addiction, the preclinical dependence evaluation and related mechanisms of various animal models are reviewed from the aspects of self-administration, drug discrimination and conditional place preference.

synthetic cathinones  /  cathinone  /  new psychoactive substance  /  dependence  /  addiction mechanism
张欢, 李贝贝, 邱云良. 合成卡西酮类物质依赖性评价及相关机制研究进展. 中国新药杂志, 2021 , 30 (5) : 403 -410 .
Huan ZHANG, Bei-bei LI, Yun-liang QIU. Dependency evaluation of synthetic cathinones and related mechanisms[J]. Chinese Journal of New Drugs, 2021 , 30 (5) : 403 -410 .
Year 2021 volume 30 Issue 5
33
8
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  • Online Date:2026-10-29
  • Published:2021-03-15
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  • Accepted:2020-10-22
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Affiliations
    1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
    2China State Institute of Pharmaceutical Industry, Shanghai InnoStar Bio-Tech Co., Ltd., Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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