Full
Outline
To systematically review the impact of patent expiry on drug price and market share, and provide evidence-based reference for promoting the balanced development of innovative drugs and generic drugs in China.
PubMed, Scopus, the Cochrane Library, CNKI, WanFang Data and VIP databases were searched to identify studies on the impact of patent expiration on the prices and market shares of original or generic drugs from inception to September 31, 2019. After relevance screening and data extraction, a standardized assessment was performed by two independent reviewers. Then, qualitative analysis was applied to evaluate the impact of patent expiration on the prices and market shares of original or generic drugs.
A total of 26 literatures were included, 10 of which were related to changes in drug prices and market shares after the expiration of patents, 14 related to changes in drug prices, and 2 related to changes in market shares. The identified studies indicated that the market shares of generic drugs ranged from 56% to 92% 1~8 years after patent expiry, and drug prices decreased to 20%~98% of the brand drug price 1~10 years after patent expiry. The prices of original prices were rigid and varied within 25%, while some even increased after generic drugs' entry.
After the expiration of patent, the overall drug prices decrease, and the original drugs show a certain price rigidity. The market share of generic drugs is increasing over time. The number of generic competitors, price discounts, and current generic drug policies could have an impact on the speed of generic substitution.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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