Full
Outline
To optimize the synthesis process of LW33.
Using 2,4,6-trichloro-5-pyrimidine-carboxaldehyde and aminomethylcyclopentane hydrochloride as starting materials, (S)-6-[(1-(4-chlorophenyl)ethyl)amino]-1-cyclopentyl-1,5,6,7-tetrahydro-4H-pyrazolo [3,4-d] pyrimidin-4-one, a novel phosphodiesterase 9A (PDE 9A) inhibitor, LW33 was synthesized through three steps.
The structure of LW33 was verified by 1H-NMR, 13C-NMR and ESI-HRMS. The verified target material LW33 was synthesized with a total yield of 43.6%, and the purity was 99.9% as determined by HPLC.
With high purity and yield, the improved process is easy to operate in a mild condition. It is suitable for further industrial production.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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