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Standardization of the first batch of national reference standard of brimonidine tartrate
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Yuan ZHANG, Ying GENG, Rong-die ZHU, Yan-lin WU, Hua GAO
Chinese Journal of New Drugs | 2021, 30(2) : 178 - 181
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Chinese Journal of New Drugs | 2021, 30(2): 178-181
Standardization of the first batch of national reference standard of brimonidine tartrate
Full
Yuan ZHANG, Ying GENG, Rong-die ZHU, Yan-lin WU, Hua GAO
Affiliations
  • National Institutes for Food and Drug Control, Beijing 102629, China
Published: 2021-01-30
Outline
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Objective:

To establish the first batch of national reference standard of brimonidine tartrate.

Methods:

The structure of brimonidine tartrate was confirmed by IR, NMR and LC-MS spectroscopy. The purity of brimonidine tartrate was determined by HPLC. Moreover, the residual solvents, residual ignition and moisture were determined. The content of brimonidine tartrate was calculated by mass balance method.

Results:

The structure of brimonidine tartrate was confirmed. The content of brimonidine tartrate was assigned as 99.8%.

Conclusion:

The first batch of national reference standard of brimonidine tartrate can be applied for the identification and content determination of brimonidine tartrate and its related preparations.

brimonidine tartrate  /  reference standard  /  content determination  /  HPLC
张媛, 耿颖, 朱容蝶, 吴彦霖, 高华. 首批酒石酸溴莫尼定国家对照品的研制. 中国新药杂志, 2021 , 30 (2) : 178 -181 .
Yuan ZHANG, Ying GENG, Rong-die ZHU, Yan-lin WU, Hua GAO. Standardization of the first batch of national reference standard of brimonidine tartrate[J]. Chinese Journal of New Drugs, 2021 , 30 (2) : 178 -181 .
Year 2021 volume 30 Issue 2
34
9
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  • Online Date:2026-10-29
  • Published:2021-01-30
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History
  • Accepted:2020-01-02
Affiliations
    National Institutes for Food and Drug Control, Beijing 102629, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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