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Outline
To study the optimal formulation process of betastin ethosomes and investigate its transdermal permeation in vitro.
Betastine ethosomes were prepared by ethanol injection method. The dosage of soybean lecithin, ethanol and water bath temperature were taken as investigation factors, particle size and entrapment efficiency were determined as evaluation indexes, and the formulation was optimized by central composite design-response surface methodology. The preliminary stability of the preparation was also investigated. Transdermal absorption test in vitro was carried out by using Franz diffusion cell to compare the effects of different ways of administration on the transdermal penetration of betastine.
The optimum prescription conditions were as follows: betastine 100 mg, soybean lecithin 311 mg, ethanol 4.1 mL, water bath temperature 39 ℃. The preparation was clear liquid with blue light, the encapsulation rate was (67.1±2.23)%, the particle size was (59.6±4.81) nm, and the difference between the actual value and the predicted value was less than 5%. The transdermal permeation rate of betastin (10.76 μg·cm-2·h-1) was 8.47 times of that of aqueous solution, 3.09 times of that of ordinary liposomes, and 1.63 times of that of 45% ethanol solution.
The prepared betastol ethosomes has the advantages of small particle size, uniform distribution, high stability and good transdermal absorption.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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