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Outline
To investigate the local anaesthetic effect and volatile composition of the extracts of Zanthoxylum bungeanum and processed products.
Pepper samples were processed by four different processing methods: frying, vinegar, salt and wine. The difference of infiltration anesthesia effect of different extracts of pepper was studied and analyzed by GC-MS. The processing method of pepper obtaining best local anesthesia effect was selected and the composition and its changes of active parts were analyzed.
The effects of different pepper extracts on guinea pigs were significantly different. When the drug concentration was 0.2 g·mL-1, the anesthesia time of different peppers was longer than 40 min, and the anesthetic effect was dose-dependent. The order of local anesthesia effect from strong to weak is: vinegar products > lidocaine hydrochloride > raw pepper > fried products > salt products > wine products. A total of 24 components were detected by GC-MS in ether extracts of different Zanthoxylum bungeanum products, which were roughly divided into three categories: alcohols, alkenes and esters. The four compounds in the highest content were: linalyl acetate, limonene, 3-decene and linalool.
The ether extracts of different products of Zanthoxylum bungeanum have better infiltrative and anesthetic action, and the effect of the vinegar product is better than that of the positive control lidocaine hydrochloride, and the specific mechanism of action is to be further studied.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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